Database : HANSEN Search on : CAMUNDONGOS NUS [Subject descriptor] References found : 15 [refine] Displaying: 1 .. 15   in format [Detailed]

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Id: 17563 Author: Zhang, Liangfen; Budiawan, Teky; Matsuoka, Masanori Title: Diversity of potential short tandem repeats in Mycobacterium leprae and application for molecular typing ..- Source: s.l; s.n; Oct. 2005. 9 p. tab. Abstract: A recent advance in molecular typing for tracing the transmission of leprosy is the discovery of short tandem repeats (STRs) in Mycobacterium leprae. To substantiate polymorphic loci from STR as promising candidates for molecular typing tools in leprosy epidemiology, 44 STR loci including 33 microsatellites and 11 minisatellites were investigated among 27 laboratory strains by sequencing PCR products. Not all STRs were necessarily polymorphic. Thirty-two out of the 44 loci were polymorphic. Nine polymorphic loci were suitable for identifying genotypes according to the discriminatory capacity, stability, and reproducibility. All the strains were classified into independent genotypes by the selected nine loci. Three multi-case households were subjected to molecular typing. M. leprae obtained from household cases showed identical copy numbers by TTC triplet alone, but the isolates from one family contact case were divided into different genotypes by adding eight other polymorphic loci. The combination of information from multiple loci allows increasing levels of discrimination and it is likely that the generation and documentation of data will result in the choice of a potential molecular typing tool for leprosy epidemiology. (AU). Descriptors: Técnica de Tipagem Bacteriana/* DNA Bacteriano/AN Pé/MI Marcadores Genéticos/*GE Hanseníase/EP/MI Camundongos Endogâmicos BALB C Camundongos Nus Repetições de Microssatélites/GE Repetições Mini-Satélites/GE Mycobacterium leprae/*CL/*GE Análise de Sequência de DNA Sequências Repetidas em Tandem/*GE Variação (Genética)/* Limits: Research Support, Non-U.S. Gov't Camundongos Humanos Animais Location: BR191.1; 09342/s

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Id: 17562 Author: Kang, Tae Jin; Yeum, Chung Eun; Kim, Byoung Chul; You, Eun-Young; Chae, Gue-Tae Title: Differential production of interleukin-10 and interleukin-12 in mononuclear cells from leprosy patients with a Toll-like receptor 2 mutation ..- Source: s.l; s.n; 2004. 7 p. ilus, tab, graf. Abstract: Toll-like receptor 2 (TLR2) is a key mediator of the immune response to mycobacterial infections, and mutations in TLR2 have been shown to confer susceptibility to infection with mycobacteria. This study investigated the profiles of cytokines, such as interferon (IFN)-gamma, interleukin (IL)-10, IL-12 and tumour necrosis factor (TNF)-alpha in response to Mycobacterium leprae in peripheral blood mononuclear cells (PBMC) with the TLR2 mutation Arg677Trp, a recently reported polymorphism that is associated with lepromatous leprosy. In leprosy patients with the TLR2 mutation, production of IL-2, IL-12, IFN-gamma, and TNF-alpha by M. leprae-stimulated PBMC were significantly decreased compared with that in groups with wild-type TLR2. However, the cells from patients with the TLR2 mutation showed significantly increased production of IL-10. There was no significant difference in IL-4 production between the mutant and wild-type during stimulation. Thus, these results suggest that the TLR2 signal pathway plays a critical role in the alteration of cytokine profiles in PBMC from leprosy patients and the TLR2 mutation Arg677Trp provides a mechanism for the poor cellular immune response associated with lepromatous leprosy. (AU). Descriptors: Sequência de Bases Interleucina-10/*BI Interleucina-12/*BI Hanseníase/GE/*IM Leucócitos Mononucleares/IM Glicoproteínas de Membrana/*GE/ME Camundongos Nus Dados de Sequência Molecular Mutação Puntual/* Receptores da Superfície Celular/*GE/ME Receptor 2 Toll-Like Receptores Toll-Like Fator de Necrose Tumoral alfa/BI Limits: Adulto Idoso Animais Feminino Humanos Masculino Camundongos Research Support, Non-U.S. Gov't Meia-Idade Location: BR191.1; 09341/s

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Id: 13790 Author: Hagge, Deanna A; Robinson, Sandra Oby; Scollard, David; McCormick, Gregory; Williams, Diana L Title: A new model for studyng the effects of Mycobacterium leprae on Schwann cell and neuron interactions ..- Source: s.l; s.n; 2002. 14 p. ilus, tab. Abstract: Millions of patients with leprosy suffer from nerve damage resulting in disabilities as a consequence of Mycobacterium leprae infection. However, mechanisms of nerve damage have not been elucidated because of the lack of a model that maintains M. leprae viability and mimics disease conditions. A model was developed using viable M. leprae, rat Schwann cells, and Schwann cell-neuron cocultures incubated at 33 degrees C. M. leprae retained 56 per cente viability in Schwann cells for 3 weeks after infection at 33 degrees C, compared with 3.6 per cente viability at 37 degrees C. Infected Schwann cells had altered morphology and expression of genes encoding cellular adhesion molecules at 33 degrees C but were capable of interacting with and myelinating neurons. Cocultures, infected after myelination occurred, showed no morphological changes in myelin architecture after 1 month of incubation at 33 degrees C, and M. leprae retained 53 per cente viability. This article describes a new model for studying the effects of M. leprae on Schwann cells. (AU). Descriptors: CAMUNDONGOS NUS HANSENIASE/microbiol HANSENIASE/patol MODELOS NEUROLOGICOS MICROSCOPIA ELETRÔNICA DE VARREDURA CELULAS CULTIVADAS NEURÔNIOS/microbiol NEURÔNIOS/patol NEURÔNIOS/fisiol COMUNICACAO CELULAR/fisiol MYCOBACTERIUM LEPRAE/cresc MYCOBACTERIUM LEPRAE/fisiol CELULAS DE SCHWANN/microbiol CELULAS DE SCHWANN/patol CELULAS DE SCHWANN/fisiol CELULAS DE SCHWANN/ultraest Limits: HUMANO ANIMAL CAMUNDONGOS RATOS SUPPORT, NON-U.S. GOV'T Electronic Medium: http://www.ilsl.br Location: BR191.1; 09030/s

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Id: 13530 Author: Hagge, Deanna; Robinson, Sandra Oby; Scollard, David; McCormick, Gregory; Williams, Diana L Title: A new model for studying the effects of Mycobacterium leprae on Schwann cell and neuron interactions ..- Source: s.l; s.n; 2002. 4 p. tab. Abstract: Millions of patients with leprosy suffer from nerve damage resulting in disabilities as a consequence of Mycobacterium leprae infection. However, mechanisms of nerve damage have not been elucidated because of the lack of a model that maintains M. leprae viability and mimics disease conditions. A model was developed using viable M. leprae, rat Schwann cells, and Schwann cell-neuron cocultures incubated at 33 degrees C. M. leprae retained 56% viability in Schwann cells for 3 weeks after infection at 33 degrees C, compared with 3.6% viability at 37 degrees C. Infected Schwann cells had altered morphology and expression of genes encoding cellular adhesion molecules at 33 degrees C but were capable of interacting with and myelinating neurons. Cocultures, infected after myelination occurred, showed no morphological changes in myelin architecture after 1 month of incubation at 33 degrees C, and M. leprae retained 53% viability. This article describes a new model for studying the effects of M. leprae on Schwann cells. (AU). Descriptors: COMUNICACAO CELULAR/fisiol CELULAS CULTIVADAS HANSENIASE/microbiol HANSENIASE/patol CAMUNDONGOS NUS MODELOS NEUROLOGICOS NEURÔNIOS/microbiol NEURÔNIOS/patol NEURÔNIOS/fisiol CELULAS DE SCHWANN/microbiol CELULAS DE SCHWANN/patol CELULAS DE SCHWANN/fisiol CELULAS DE SCHWANN/ultraest MICROSCOPIA ELETRÔNICA DE VARREDURA MYCOBACTERIUM LEPRAE/cresc MYCOBACTERIUM LEPRAE/fisiol Limits: ANIMAL HUMANO CAMUNDONGOS RATOS SUPPORT, NON-U.S. GOV'T Location: BR191.1; 08982/s

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Id: 13527 Author: Lancaster, R. D; McDougall, A. C; Hilson, G. R. F; Colston, M. J Title: Leprosy in the nude mouse ..- Source: s.l; s.n; 1984. 4 p. tab, graf. Abstract: The continued failure to grow the leprosy bacillys in vitro and the limited and localized nature of the infection resulting from the inoculation of Mycobacterium leprae into normal mice emphasise the need for an experimental animal which readily permits growth of the bacillus. (AU). Descriptors: HANSENIASE/fisiopatol CAMUNDONGOS NUS/microbiol MODELOS ANIMAIS DE DOENCAS Limits: ANIMAL CAMUNDONGOS SUPPORT, NON-U.S. GOV'T Location: BR191.1; 08972/s

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Id: 13220 Author: Rees, R. J; McDougall, A. C;; Weddell, A. G Title: The testis in mice infected with Mycobacterium leprae ..- Source: s.l; s.n; feb. 1975. 7 p. ilus, tab. Abstract: Following inoculation either locally or intravenously with Mycobact. leprae of human origin, the histopathology and bacteriology of the testis in experimental mice is described. Normal mice, and mice rendered immunologically deficient by thymectomy and whole-body irradiation, were studied. Attention is drawn to a heavy bacillation of the testis in mice from both groups. Bacilli were found in and beneath the tunica albuginea, but mainly in interstitial cells and in macrophages surrounding the tubules. The percentage of solidly staining bacilli was high, and globi were frequent. The study showed that the testis in mice is particularly favourable for the lodgement and multiplication of Mycobact. laprae following either local or intravenous inoculation. The significance of this in relation to the metabolism of the leprosy bacillus and to the frequent occurrence of testicular damage in the lepromatous male patient is discussed. This work was supported by grants to A. G. M. Weddell and A. C. McDougall from the Medical Research Council and the British Leprosy Relief Association (LEPRA).(AU). Descriptors: HANSENIASE/microbiol HANSENIASE/patol IMUNOSSUPRESSAO CAMUNDONGOS ENDOGÂMICOS CBA CAMUNDONGOS NUS MYCOBACTERIUM LEPRAE/isol TESTICULO/microbiol TESTICULO/patol TIMECTOMIA IMUNIDADE/ef rad Limits: ANIMAL MASCULINO CAMUNDONGOS Electronic Medium: http://www.ilsl.br Location: BR191.1; 01582/s

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Id: 13217 Author: Portaels, F; Ridder, K. de; Pattyn, S. R Title: Cultivable mycobacteria isolated from organs of armadillos uninoculated and inoculated with Mycobacterium leprae ..- Source: s.l; s.n; Mar.-Apr. 1985. 10 p. tab. Abstract: Mycobacteria were cultivated from 16 out of 32 samples of tissues from armadillos inoculated with Mycobacterium leprae. Three out of 7 samples from non-inoculated armadillos held in captivity were also positive for cultivable mycobacteria. Some isolated strains belonged to the M. avium-intracellulare-scrofulaceum complex, while others were identified as M. gordonae and M. terrae. Unclassified mycobacteria were isolated from M. leprae-inoculated armadillos only. Taxonomic studies confirmed that these new armadillo-derived mycobacteria (ADM) are different from all presently known species of mycobacteria, including M. leprae. The same new species were isolated from different armadillo colonies and were never found in non-inoculated animals. Different factors influence the isolation of these ADM in primary culture. Analysis of some specific markers of these ADM has been suggested in order to quantitatively determine the proportion of these ADM to M. leprae in armadillo tissues. No mycobacteria were cultivated from Nude mouse footpads infected with M. leprae.(AU). Descriptors: TATUS/microbiol HANSENIASE/microbiol CAMUNDONGOS NUS MYCOBACTERIUM/clas MYCOBACTERIUM/cresc MYCOBACTERIUM/isol LINFONODOS/microbiol MYCOBACTERIUM LEPRAE Limits: ANIMAL CAMUNDONGOS SUPPORT, NON-U.S. GOV'T Electronic Medium: http://www.ilsl.br Location: BR191.1; 02168/s

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Id: 13198 Author: Lancaster, R. D; McDougall, A. C; Hilson, G. R; Colston, M. J Title: Leprosy in the nude mouse ..- Source: s.l; s.n; 1984. 4 p. tab, graf. Abstract: The continued failure to grow the leprosy bacillus in vitro and the limited and localized nature of the infection resulting from the inoculation of Mycobacterium leprae into normal mice emphasise the need for an experimental animal which readily permits growth of the bacillus.(AU). Descriptors: HANSENIASE/fisiopatol CAMUNDONGOS NUS/microbiol MODELOS ANIMAIS DE DOENCAS Limits: CAMUNDONGOS ANIMAL SUPPORT, NON-U.S. GOV'T Electronic Medium: http://www.ilsl.br Location: BR191.1; 02106/s

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Id: 11757 Author: Chae, Gue-Tae; Kim, Min-Joo; Kang, Tae-Jin; Lee, Seong-Beom; Shin, Hang-Kye; Kim, Jong-Pill; Ko, Young-Hoon; Kim, Sung-Hwa; Kim, Nan-Hee Title: DNA-PCR and RT-PCR for the 18-KDa gene of Mycobacterium leprae to asses the efficacy of multi-drug therapy for leprosy ..- Source: s.l; s.n; 2002. 6 p. tab. Descriptors: PROTEINAS DE BACTÉRIAS BIOPSIA DNA BACTERIANO DENSITOMETRIA QUIMIOTERAPIA COMBINADA ELETROFORESE EM GEL DE AGAR GLICOLIPIDIOS LEPROSTATICOS HANSENIASE HANSENIASE ESTUDOS LONGITUDINAIS CAMUNDONGOS MYCOBACTERIUM LEPRAE MYCOBACTERIUM LEPRAE MYCOBACTERIUM LEPRAE REAÇAO EM CADEIA POR POLIMERASE RNA MENSAGEIRO REPRODUTIBILIDADE DE RESULTADOS IMUNOGLOBULINA M/BL CAMUNDONGOS REACAO EM CADEIA POR POLIMERASE VIA TRANSCRIPTASE CAMUNDONGOS NUS REACAO EM CADEIA POR POLIMERASE VIA TRANSCRIPTASE REVERSA Limits: ANIMAL Location: BR191.1; 08517/s

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Id: 11322 Author: Naito, Mariko; Matsuoka, Masanori; Ohara, Naoya; Nomaguchi, Hiroko; Yamada, Takeshi Title: The antigen 85 complex vaccine against experimental mycobacterium leprae infection in mice ..- Source: s.l; s.n; 2000. 4 p. tab, graf. Descriptors: ANTIGENOS DE BACTÉRIAS VACINAS BACTERIANAS INTERFERON TIPO II HANSENIASE CAMUNDONGOS CAMUNDONGOS ENDOGAMICOS BALB C MYCOBACTERIUM LEPRAE BAÇO BAÇO CAMUNDONGOS NUS Limits: ANIMAL Location: BR191.1; 07261/s

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Id: 11272 Author: Ohara, Naoya; Matsuoka, Masanori; Nomaguchi, Hiroko; Naito, Mariko; Yamada, Takeshi Title: Inhibition of multiplication of mycobacterium leprae in mouse foot pads by recombinant bacillus Calmette-Guerin (BCG) ..- Source: s.l; s.n; 2000. 4 p. graf. Descriptors: ANTIGENOS DE BACTÉRIAS VACINA BCG CONTAGEM DE COLONIA MICROBIANA PÉ IMUNIZAÇAO HANSENIASE HANSENIASE HANSENIASE CAMUNDONGOS CAMUNDONGOS ENDOGAMICOS BALB C MYCOBACTERIUM LEPRAE MYCOBACTERIUM LEPRAE VACINAS SINTÉTICAS CAMUNDONGOS NUS Location: BR191.1; 07452/s

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Id: 10162 Author: Ishaque, M; Sticht-Groh, V; Tologa, D Title: Susceptibility of severe combined immunodeficient mice to Mycobacterium leprae ..- Source: s.l; s.n; 1996. 8 p. tab. Descriptors: CONTAGEM DE COLONIA MICROBIANA MEIOS DE CULTIVO CONDICIONADOS MEIOS DE CULTURA PÉ HOSPEDEIRO IMUNOCOMPROMETIDO HANSENIASE HANSENIASE CAMUNDONGOS CAMUNDONGOS SCID MYCOBACTERIUM LEPRAE CAMUNDONGOS NUS Limits: ESTUDO COMPARATIVO ANIMAL Location: BR191.1; 07075/s

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Id: 10101 Author: Sampoonachot, Prasert; Bundit, Chaiwut; Kuhacharoen, Nunta; Peerapakorn, Somchai; Kampirapap, Kowit; Poomlek, Arphorn; Bampenyu, Sawanee; Tiasiri, Sirisavapa; Rungruang, Seri; Surasondhi, Somchai; Supanwanit, Sakchai; Wiriyawipart, Srisunthon Title: Ofloxacin containing combined drug regimens in the treatment of multibacillary leprosy ..- Source: s.l; s.n; 1997. 8 p. tab. Descriptors: ADOLESCENCIA CRIANÇA RELAÇAO DOSE-RESPOSTA A DROGA LEPROSTATICOS LEPROSTATICOS HANSENIASE HANSENIASE CAMUNDONGOS OFLOXACINA OFLOXACINA RIFAMPINA RIFAMPINA TAILANDIA FATORES DE TEMPO RESULTADO DE TRATAMENTO CAMUNDONGOS NUS Limits: ESTUDO COMPARATIVO ANIMAL Location: BR191.1; 07042/s

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Id: 10028 Author: Kurabachew, Mekonnen; Wondimu, Assefa; Ryon, Judith J Title: Reverse transcription-PCR detection of Mycobacterium leprae in clinical specimens ..- Source: s.l; s.n; 1998. 5 p. ilus, tab. Descriptors: PRIMERS DO DNA HANSENIASE CAMUNDONGOS MYCOBACTERIUM LEPRAE REAÇAO EM CADEIA POR POLIMERASE RNA BACTERIANO RNA RIBOSSOMICO 16S SENSIBILIDADE E ESPECIFICIDADE PELE CAMUNDONGOS NUS Limits: ANIMAL Location: BR191.1; 06993/s

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Id: 9908 Author: Randhawa, B; Harris, E. B; Prabhakaran, K; Hastings, R. C Title: Bactericial action of ampicillin/sulbactam against Mycobacterium leprae ..- Source: s.l; s.n; 1994. 3 p. graf. Descriptors: AMPICILINA ANTIBIOTICOS COMBINADOS PÉ HANSENIASE HANSENIASE CAMUNDONGOS CAMUNDONGOS ENDOGAMICOS A CAMUNDONGOS ENDOGAMICOS BALB C MYCOBACTERIUM LEPRAE SULBACTAM Camundongos Nus Limits: ANIMAL Location: BR191.1; 06883/s

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